Reason: There are browser compatibility issues with Angular.
Some of the ES6 script functions and methods are not supported in IE.
Solution: add these following script headers in your head section of index.html along with the polyfills tags
<script src="https://cdnjs.cloudflare.com/ajax/libs/es5-shim/4.4.1/es5-shim.js"></script>
<script src="https://cdnjs.cloudflare.com/ajax/libs/es6-shim/0.34.1/es6-shim.js"></script>
<script src="https://cdnjs.cloudflare.com/ajax/libs/systemjs/0.19.20/system-polyfills.js"></script>
<script src="https://npmcdn.com/angular2/es6/dev/src/testing/shims_for_IE.js"></script>
Source: Another Answer on stackoverflow