If you're okay with a (very good) estimate, the file size is 75% of the size of the base64 string. The true size is no larger than this estimate, and, at most, two bytes smaller.
If you want to write one line and be done with it, use atob()
and check the length, as in the other answers.
If you want an exact answer with maximum performance (in the case of gigantic files or millions of files or both), use the estimate but account for the padding to get the exact size:
let base64Length = src.length - (src.indexOf(',') + 1);
let padding = (src.charAt(src.length - 2) === '=') ? 2 : ((src.charAt(src.length - 1) === '=') ? 1 : 0);
let fileSize = base64Length * 0.75 - padding;
This avoids parsing the entire string, and is entirely overkill unless you're hunting for microoptimizations or are short on memory.