Apache HTTPD is a generic web server. Node.js is a development framework that includes a standard library for creating HTTP servers. Thus, there isn't a standard configuration for a Node.js based application like there is for Apache HTTPD.
The basic example of writing a web server with Node.js is found at https://nodejs.org/api/synopsis.html#synopsis_example
const http = require('http');
const hostname = '127.0.0.1';
const port = 3000;
const server = http.createServer((req, res) => {
res.statusCode = 200;
res.setHeader('Content-Type', 'text/plain');
res.end('Hello World\n');
});
server.listen(port, hostname, () => {
console.log(`Server running at http://${hostname}:${port}/`);
});
Which is to say, you define where files are loaded from and what port they are served over.
This is where frameworks like Fastify, Hapi, and Express come in. The make it easier to write generic web servers.