It depends on what do you mean for "safe".
User should have the fonts, so you must include the relative font, and in various formats: there is not yet a format recognized by most used web-browsers.
Additionally, font with multiple colours are not fully understood by various systems, so you should care about what do you expect from users (click, select, copy, etc.).
Additionally, every fonts has own design, so between different fonts (so browsers and operating system) things can look differently. We do not have yet a "Helvetica 'Home'", a "Times New Roman 'Home'".
All this points, could be solved by using a web font, with monochrome glyphs (but it could be huge, if it includes all Unicode code points (+ usual combinations).
It seems that various recent browser crashes if there are many different glyphs, but usually it should not be a problem.
I also recommend aria
stuffs so that you page could be used also by e.g. readers (and braille screen).
Note: on the plus side, the few people that use text browser can better see the HOME (not the case in case of an image), if somebody still care about this use case.