Since you need to watch for a specific file change on Windows, you may check this SO post which cover this case.
From this post, there is a link to a valid example using Python's win32 API:
import os
import win32file
import win32event
import win32con
path_to_watch = os.path.abspath (".")
#
# FindFirstChangeNotification sets up a handle for watching
# file changes. The first parameter is the path to be
# watched; the second is a boolean indicating whether the
# directories underneath the one specified are to be watched;
# the third is a list of flags as to what kind of changes to
# watch for. We're just looking at file additions / deletions.
#
change_handle = win32file.FindFirstChangeNotification (
path_to_watch,
0,
win32con.FILE_NOTIFY_CHANGE_FILE_NAME
)
#
# Loop forever, listing any file changes. The WaitFor... will
# time out every half a second allowing for keyboard interrupts
# to terminate the loop.
#
try:
old_path_contents = dict ([(f, None) for f in os.listdir (path_to_watch)])
while 1:
result = win32event.WaitForSingleObject (change_handle, 500)
#
# If the WaitFor... returned because of a notification (as
# opposed to timing out or some error) then look for the
# changes in the directory contents.
#
if result == win32con.WAIT_OBJECT_0:
new_path_contents = dict ([(f, None) for f in os.listdir (path_to_watch)])
added = [f for f in new_path_contents if not f in old_path_contents]
deleted = [f for f in old_path_contents if not f in new_path_contents]
if added: print "Added: ", ", ".join (added)
if deleted: print "Deleted: ", ", ".join (deleted)
old_path_contents = new_path_contents
win32file.FindNextChangeNotification (change_handle)
finally:
win32file.FindCloseChangeNotification (change_handle)
Alternatively, you may check the python library called Watchdog, that aims to provide this kind of feature on all common platforms (Unix / Windows).
In both case, the idea is to create a script that react on a file change on filesystem. This uses OS specific events / interrupts to notify your script that something may interest you. This is less expansive than actively polling your file (checking for a string every second).