here are the definations from MSDN,
4.0 (the default). The HttpRequest object internally sets a flag that indicates that request validation should be triggered whenever any HTTP request data is accessed. This guarantees that the request validation is triggered before data such as cookies and URLs are accessed during the request. The request validation settings of the pages element (if any) in the configuration file or of the @ Page directive in an individual page are ignored.
2.0. Request validation is enabled only for pages, not for all HTTP requests. In addition, the request validation settings of the pages element (if any) in the configuration file or of the @ Page directive in an individual page are used to determine which page requests to validate.
but I don't follow, can some help to explain a little bit?