You need to tell Windows to set it's focus on the Browser Window, and then send the correct key command.
For instance, this code snippet will set focus to the browser and send the "DOWN" key to the browser window.
[DllImport("user32.dll")]
private static extern IntPtr SetFocus(IntPtr hWnd);
[DllImport("user32.dll")]
[return: MarshalAs(UnmanagedType.Bool)]
private static extern bool SetForegroundWindow(IntPtr hWnd);
private void SendDownKey(Browser browser)
{
SetForegroundWindow(browser.document.DomContainer.hWnd);
SetFocus(browser.document.DomContainer.hWnd);
SendKeys.SendWait("{DOWN}");
}