This is an old question, however no one wrote a solution for without loading the excel file. Assuming the excel file is too huge, this will be inefficient to load the existing file and save on it. Instead is there any method to append, like for ordinary files?
df is the dataframe I would like to append
df.to_excel(folder+"file.xlsx", header=False, index=False)
However file.xlsx exists and there is another df with the same headers.
How can I append df to existing file.xlsx, without loading file.xlsx?