Aside from the obvious candidates (illegal filepath, permissions error), the problem could even be mutex locking:
https://issues.apache.org/jira/browse/LOG4NET-506
RollingFileAppender locking log folder in some cases
Abstract:
In some configuration cases, the rolling file appender may
issue a mutex lock on the folder name. If more than one processes try
to do that with different executing identity, only one will be able to
log to its specific logs file. The others will no more be able to do
it.
SUGGESTION:
Add this line to your app.config/web.config, under appSettings, to enable internal debugging:
<add key="log4net.Internal.Debug" value="true"/>
This will give you output like this, to both the system console and to System.Diagnostics.Trace
log4net:ERROR Could not create Appender [RollingLogFileAppender] of type [log4net.Appender.RollingFileAppender]. Reported error follows.
System.UnauthorizedAccessException: Access to path 'D__Logs_' denied. (Translated from french)
à System.IO.__Error.WinIOError(Int32 errorCode, String maybeFullPath)
à System.Threading.Mutex.MutexTryCodeHelper.MutexTryCode(Object userData)
à System.Runtime.CompilerServices.RuntimeHelpers.ExecuteCodeWithGuaranteedCleanup(TryCode code, CleanupCode backoutCode, Object userData)
à System.Threading.Mutex.CreateMutexWithGuaranteedCleanup(Boolean initiallyOwned, String name, Boolean& createdNew, SECURITY_ATTRIBUTES secAttrs)
à System.Threading.Mutex..ctor(Boolean initiallyOwned, String name, Boolean& createdNew, MutexSecurity mutexSecurity)
à System.Threading.Mutex..ctor(Boolean initiallyOwned, String name, Boolean& createdNew)
à log4net.Appender.RollingFileAppender.ActivateOptions()
à log4net.Repository.Hierarchy.XmlHierarchyConfigurator.ParseAppender(XmlElement appenderElement)
log4net:ERROR Appender named [RollingLogFileAppender] not found.
Please try this, and post back what you find!