I tried to use this script to prevent windows screen lock. The script works for moving the mouse, but it doesn't prevent windows 10 from locking.
import pyautogui
import time
import win32gui, win32con
import os
Minimize = win32gui.GetForegroundWindow()
win32gui.ShowWindow(Minimize, win32con.SW_MINIMIZE)
x = 1
while x == 1:
pyautogui.moveRel(1)
pyautogui.moveRel(-1)
time.sleep (300)