In the spirit of "might not be to late to add my 2 cents" as in @Alvin's answer's case, here is something I'd think about: if your application is meant to last for some years, it is going to face several changes in how applications and systems work.
For instance, let's say you were thinking about this 10 years ago. I was watching Dexter back then, but I guess you actually have memories of how things were at that time. From what I can tell, multithreading was not much of an issue to developers of 2000, and now it is. So Moore's law broke for them. Before that people didn't even care about what will happen in "Y2K".
Speaking of Moore's law, processors are indeed getting quite fast, so maybe certain optimizations won't be even that necessary. And possibly the array of optimizations will be much bigger, some processors are getting optimizations for several server-centric stuff (XML, cryptography, compression and regex! I am surprised such things can get done on a chip) and also spend less energy (which is probably very important for warfare hardware...).
My point being that focusing on what exist today as a platform for tomorrow is not a good idea. Make it work today, and surely it will work tomorrow (backward-compatibility is especially valued by Microsoft, Apple is not bad it seems and Linux is very liberal about making it work as you want).
There is, yes, one thing that you can do. Attach your technology to something that just won't (likely) die, such as Javascript. I'm serious, Javascript VMs are getting terribly efficient nowdays and are just going to get better, plus everyone loves it so it's not going to dissappear suddenly. If needing more efficiency/features, maybe target the CRL or JVM?
Also I believe multithreading will become more and more of an issue. I have a gut feeling the number of processor cores will have a Moore's law of their own. And architectures are more than likely to change, from the looks of the cloud buzz.
PS: In any case, I belive C optimizations of the past are still quite valid under modern compilers!