If by that you mean how can you insert a non-unicode string the answer is: the same way as you would put any other string. Just be careful when you create the column to select an encoding that supports it (for example utf8-mb4 - that means utf8 on 4 bytes, because the default mysql utf8 only uses 3 and... long story here actually :) - should do the trick for mostly anyhting you want to put there).
Then... INSERT INTO tableName
(columnName
) VALUES ('yourString');
Important note here: You should convert that string to the encoding you use before (again... utf8 would be your best choice). If you don't do that and respect the next paragraph (check below) you are still fine, but if you don't you will end up with messed up stuff.
Just be careful on data processing unfortunately mysql has so many points of failure regarding encoding. It has 1 encoding for db, 1 for table, 1 for column, 1 for data saving, even 1 for the connection so... just try to use the same for all to avoid surprises.