You have quite a few syntax errors in your code, check the comments to see where you could improve, with some reading material at the bottom!
num1 = int(input("Enter in the first number")) # You need to cast your input to a int, input stores strings.
num2 = int(input("Enter in the second number")) # Same as above, cast as INT
sign = input("Enter in the calculator operator you would like")
# You cannot use `elif` before declaring an `if` statement. Use if first!
if sign == "+": # = will not work, you need to use the == operator to compare values
print(num1 + num2)
elif sign == "-": # = will not work, you need to use the == operator to compare values
print(num1 - num2)
elif sign == "*": # = will not work, you need to use the == operator to compare values
print(num1*num2)
elif sign == "/": # = will not work, you need to use the == operator to compare values
print(num1/num2)
Code will work fine with these changes, however you should read up on Python Syntax and Operators!
Happy learning!