I am facing CryptographicException: The system cannot find the file specified error when application is hosted on azure on using certificates? For now all i can see is that we have to add WEBSITE_LOAD_USER_PROFILE=1 to app settings in azure if we are using azure app services. But how do we achieve it if we are not using app services
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No, you can't.
Even if you use IIS 7, your option is to set Load User Profile
option as True
in the IIS Application Pool configuration, you could not set it in the web config file. If you use other cloud services, I think there also should be a setting like WEBSITE_LOAD_USER_PROFILE
in azure.
For more details, you could refer to the links below.

Joy Wang
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For me things did't work even after setting `WEBSITE_LOAD_USER_PROFILE` to 1 when my app service plan was using `Free` tier. It started to work after I upgraded it to `S1` tier. – RBT Nov 22 '21 at 09:38