Regex are a cumbersome way to validate that numbers lie within a range, but it is possible. I'd recommend validating the numeric values in some other way if possible. If you must use regex, here's the basic concept for validating a numeric range:
Since regular expressions deal with text rather than with numbers, matching a number in a given range takes a little extra care. You can’t just write [0-255] to match a number between 0 and 255. Though a valid regex, it matches something entirely different. [0-255] is a character class with three elements: the character range 0-2, the character 5 and the character 5 (again). This character class matches a single digit 0, 1, 2 or 5, just like [0125].
Matching the three-digit numbers is a little more complicated, since we need to exclude numbers 256 through 999. 1[0-9][0-9] takes care of 100 to 199. 2[0-4][0-9] matches 200 through 249. Finally, 25[0-5] adds 250 till 255.
Putting this all together using alternation we get: [0-9]|[1-9][0-9]|1[0-9][0-9]|2[0-4][0-9]|25[0-5]. This matches the numbers we want, with one caveat: regular expression searches usually allow partial matches, so our regex would match 123 in 12345. There are two solutions to this.
(full text at https://www.regular-expressions.info/numericranges.html)
I'm lazy, so instead of building a huge regex to match 1-65536 by hand I used http://gamon.webfactional.com/regexnumericrangegenerator/. The result:
([1-9]|[1-8][0-9]|9[0-9]|[1-8][0-9]{2}|9[0-8][0-9]|99[0-9]|[1-8][0-9]{3}|9[0-8][0-9]{2}|99[0-8][0-9]|999[0-9]|[1-5][0-9]{4}|6[0-4][0-9]{3}|65[0-4][0-9]{2}|655[0-2][0-9]|6553[0-6])
Plugging this into your regex from above, we get this (running in chrome devtools console):
new RegExp(
"^"
+ "[0-9a-fA-F]{8}\-[0-9a-fA-F]{4}\-[0-9a-fA-F]{4}\-[0-9a-fA-F]{4}\-[0-9a-fA-F]{12}"
+ ":"
+ "([1-9]|[1-8][0-9]|9[0-9]|[1-8][0-9]{2}|9[0-8][0-9]|99[0-9]|[1-8][0-9]{3}|9[0-8][0-9]{2}|99[0-8][0-9]|999[0-9]|[1-5][0-9]{4}|6[0-4][0-9]{3}|65[0-4][0-9]{2}|655[0-2][0-9]|6553[0-6])"
+ ":"
+ "([1-9]|[1-8][0-9]|9[0-9]|[1-8][0-9]{2}|9[0-8][0-9]|99[0-9]|[1-8][0-9]{3}|9[0-8][0-9]{2}|99[0-8][0-9]|999[0-9]|[1-5][0-9]{4}|6[0-4][0-9]{3}|65[0-4][0-9]{2}|655[0-2][0-9]|6553[0-6])"
+ "$"
).test("7e21dc49-8640-4982-b3eb-51608b680e3c:1:65536")
>> true
Full regex:
^[0-9a-fA-F]{8}\-[0-9a-fA-F]{4}\-[0-9a-fA-F]{4}\-[0-9a-fA-F]{4}\-[0-9a-fA-F]{12}:([1-9]|[1-8][0-9]|9[0-9]|[1-8][0-9]{2}|9[0-8][0-9]|99[0-9]|[1-8][0-9]{3}|9[0-8][0-9]{2}|99[0-8][0-9]|999[0-9]|[1-5][0-9]{4}|6[0-4][0-9]{3}|65[0-4][0-9]{2}|655[0-2][0-9]|6553[0-6]):([1-9]|[1-8][0-9]|9[0-9]|[1-8][0-9]{2}|9[0-8][0-9]|99[0-9]|[1-8][0-9]{3}|9[0-8][0-9]{2}|99[0-8][0-9]|999[0-9]|[1-5][0-9]{4}|6[0-4][0-9]{3}|65[0-4][0-9]{2}|655[0-2][0-9]|6553[0-6])$