I want to create an application domain with default permissions and load assembly into the application domain with default privileges and execute the methods inside the assembly.
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You may take a look at the following article on MSDN. Or if you want to construct an instance of some type inside another AppDomain (assuming this type has a default constructor):
var domain = AppDomain.CreateDomain("NewAppDomain");
var path = @"C:\work\SomeAssembly.dll";
var t = typeof(SomeType);
var instance = (SomeType)domain.CreateInstanceFromAndUnwrap(path, t.FullName);
The instance
variable returned with this method lives on your newly created application domain and you are ready to manipulate it.

Darin Dimitrov
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5The link you referenced is dead. – tvanfosson Jun 25 '13 at 18:38
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Perhaps this helps
Can I reload an assembly in Mono CSharpRepl?
var dom = AppDomain.CreateDomain("tmp");
dom.Load("System.Core");
AppDomain.Unload(dom);
See also