To monitor uptime, you would use a Cron job on the system. With each call, you would check to see if the host is up, and how long it would take. And in that script, you would save your data in Redis.
To do this in Node.JS, you would create a script that checks the status of the server. Just making a HTTP request to the server (Or Ping, w.e.) and recording if it fails or not. Then I would just record it to Redis. How you do it does not matter, because the script (if you run the cron every 30 seconds) has [30] seconds before the next run, so you dont have to worry about getting your query to the server. How you save your data is up to you, but in this case even MySQL would work (if you are only doing a small number of sites)
More on Cron @ Wikipedia