i've actually never encounter this problem before. I usually start designing my layout in photoshop then transfer it to my page.
Somehow, lately i've been using georgia font alot, and i love it when the style is italic, but what comes out in photoshop does not reflect back in the webpage when i set it in css.
in the pic above, 1. is what i saw in photoshop and what i wanted, but 2. is what i got, no matter what i try changing, be it font-weight or font-size it remains as bold. I want it thinner, is there a way? I tried font-stretch too btw.