I would think that a multi-web server and a distributed second level cache can -and probably should- coexist.
First of all if we take as example memcached, it supports distributed object storing so if you're not using that, you could switch to that. it works.
Secondly, I'm guessing that you're introducing the web-server farm to respond to increasing web requests which will in turn mean increasing requests for data. If you kill your caching, it won't matter how much you optimize your database you're going to thrash it with queries. So you are going to improve your execution time, but while you wait for the database to return your data.
This is especially true for the case that web-node 1 requests dataset A and web-node 2 requests dataset A --> you are going to do the same query twice while with second level caching you only do it once.
So my recommendation is:
Don't kill your second level cache. You have already spent resources to implement it and by disabling it you are NOT going to improve your application's performance. Even a single node of memcached is going to be faster than having none at all.
Do optimize your database operations. This means both from the database side (indexes, views, sp's, functions, perhaps a cluster with read-only and write-only nodes) and application side (optimize your queries, lazy/eager loading profiling, don't fetch data you don't need, combine multiple queries into single-round-trips via Future, MutliQuery, MultiCriteria)
Do optimize your second-level cache implementation. There are datasets that have an infinite expiration date, and thus you query the db for them only once, and there are datasets that have short expiration dates, and thus probably expensive queries are executed more frequently. By optimizing your queries and your db you are going to improve the performance for the queries but the second-level cache is going to save your skin on peak load where short-expiration date datasets will be fetched by the cache more frequently.
If using textual queries is an everyday operation use the database's full-text capabilities or, even better, use a independent service like Lucene.NET (which can be integrated with NHibernate via NHibernate.Search)