Best way is to make these column a unique composite key. But here is a query to delete all records other than your desired result.
delete from Table_1
where
Col1=(SELECT Col1
FROM table_1
GROUP BY Col1, Col2
HAVING Count(*) > 1)
And
Col2 =(SELECT Col2
FROM table_1
GROUP BY Col1, Col2
HAVING Count(*) > 1)
this might not be the most optimized and efficient query but it works. if you don't want to delete duplicated records and just retrieve unique ones:
SELECT Col1,Col2
FROM table_1
GROUP BY Col1, Col2
HAVING Count(*) = 1
To get duplicating records:
SELECT Col2,Col1
FROM table_1
GROUP BY Col1, Col2
HAVING Count(*) > 1