This is worth asking. When Windows 8 was demonstrated in June, a couple of comments by the presenter scared quite a few developers - or at least turned the Internet into panic mode. I'm surprised this question hasn't been asked here before.
The best article on the topic I have found is Windows 8 for Software Developers on Ars Technica.
The short answer is: it will remain the same.
The long answer is: it will remain the same, but several things will be added. You may want to pursue using those if you're willing to bet on new Microsoft technologies. One particularly interesting one is WinRT, which is a new object-oriented native code API exposed through COM, which is supposed to be a new version of the old flat Win32 API. Details are in the linked article.
It is very, very, very, very unlikely that anything that already exists, especially based on Win32 or .Net, would be removed. That means your existing programs written in .Net or native C++ or Delphi will continue to work fine. It is also unlikely that the primary development platform will be HTML. More likely is that HTML applications will be encourage for specific scenarios - perhaps touchscreen, kiosks and tablets.
I'd encourage you to read the article I linked to above - it covers this in far more detail than any answer here can.