Everything is well explained in [Python.Docs]: ctypes - A foreign function library for Python:
class ctypes.CDLL(name, mode=DEFAULT_MODE, handle=None, use_errno=False, use_last_error=False, winmode=0)
Instances of this class represent loaded shared libraries. Functions in these libraries use the standard C calling convention, and are assumed to return int.
...
class ctypes.LibraryLoader(dlltype)
...
LoadLibrary(name)
Load a shared library into the process and return it. This method always returns a new instance of the library.
These prefabricated library loaders are available:
ctypes.cdll
Creates CDLL instances.
So, the 2nd form is just a convenience wrapper, there's absolutely no functional difference between them, as shown below:
Win:
[cfati@CFATI-5510-0:e:\Work\Dev\StackOverflow\q067049436]> "e:\Work\Dev\VEnvs\py_pc064_03.10_test0\Scripts\python.exe"
Python 3.10.9 (tags/v3.10.9:1dd9be6, Dec 6 2022, 20:01:21) [MSC v.1934 64 bit (AMD64)] on win32
Type "help", "copyright", "credits" or "license" for more information.
>>>
>>> import ctypes as cts
>>>
>>>
>>> k32_1 = cts.CDLL("kernel32.dll") # 1.
>>> k32_21 = cts.cdll.LoadLibrary("kernel32.dll") # 2.1.
>>> k32_22 = cts.cdll.kernel32 # 2.2.
>>>
>>> k32_1, k32_21, k32_22
(<CDLL 'kernel32.dll', handle 7fff59100000 at 0x2335c444ee0>, <CDLL 'kernel32.dll', handle 7fff59100000 at 0x2335b44bc10>, <CDLL 'kernel32', handle 7fff59100000 at 0x2335c45a790>)
>>>
>>> type(k32_1), type(k32_21), type(k32_22)
(<class 'ctypes.CDLL'>, <class 'ctypes.CDLL'>, <class 'ctypes.CDLL'>)
>>>
>>> k32_1._handle == k32_21._handle == k32_22._handle
True
Technically, WinDLL (windll) should be used here, but since Python is 064bit (pc064), CDLL (cdll) is also fine
Nix:
(qaic-env) [cfati@cfati-5510-0:/mnt/e/Work/Dev/StackOverflow/q067049436]> ll $(pwd)/../q074171783/*.so
-rwxr-xr-x 1 cfati cfati 16376 Oct 23 22:37 /mnt/e/Work/Dev/StackOverflow/q067049436/../q074171783/dll00.so*
-rwxr--r-- 1 cfati cfati 9728 Oct 23 22:40 /mnt/e/Work/Dev/StackOverflow/q067049436/../q074171783/dll00_wincopy.so*
lrwxrwxrwx 1 cfati cfati 8 Jan 11 10:50 /mnt/e/Work/Dev/StackOverflow/q067049436/../q074171783/libdll00.so -> dll00.so*
(qaic-env) [cfati@cfati-5510-0:/mnt/e/Work/Dev/StackOverflow/q067049436]>
(qaic-env) [cfati@cfati-5510-0:/mnt/e/Work/Dev/StackOverflow/q067049436]> LD_LIBRARY_PATH=${LD_LIBRARY_PATH}:$(pwd)/../q074171783 python
Python 3.8.10 (default, Nov 14 2022, 12:59:47)
[GCC 9.4.0] on linux
Type "help", "copyright", "credits" or "license" for more information.
>>>
>>> import ctypes as cts
>>>
>>>
>>> ld0_1 = cts.CDLL("libdll00.so") # 1.
>>> ld0_21 = cts.cdll.LoadLibrary("libdll00.so") # 2.1.
>>> #ld0_22 = cts.cdll.libdll00 # 2.2.
>>>
>>> ld0_1, ld0_21
(<CDLL 'libdll00.so', handle 11f9510 at 0x7fbb9576cca0>, <CDLL 'libdll00.so', handle 11f9510 at 0x7fbb95754eb0>)
>>>
>>> type(ld0_1), type(ld0_21)
(<class 'ctypes.CDLL'>, <class 'ctypes.CDLL'>)
>>>
>>> ld0_1._handle == ld0_21._handle
True
#2.2. (commented) doesn't work here, since the file extension must be part of the string passed to [Man7]: DLOPEN (3) (otherwise it doesn't find it - maybe this could be worked around a Ld script?).
The closest thing that I could find is cts.cdll["libdll00.so"]
(but it still looks more related to the other options)
Use whatever suits you best.
2nd form (#2.2.) is shorter (I suppose this is its purpose).
#1. and #2.1. are the same (#2.1. is probably more explanatory (as it has LoadLibrary)) and they allow you to load a library from a custom path, or with an extension different than the default. Personally, #1. is the one I prefer.
For more details, you can take a look at [GitHub]: python/cpython - (master) cpython/Lib/ctypes/__init__.py, especially the LibraryLoader at implementation which (cdll actually is, and) is easy to understand.
Just a heads-up (probably you already know what you're getting into): loading and unloading libraries can sometimes be tricky:
You might also want to check [SO]: C function called from Python via ctypes returns incorrect value (@CristiFati's answer) for a common pitfall encountered when calling functions via CTypes.