I have a r markdown file, and was curious if it's possible to run code chunks direct from a pdf after it's been knitted ?
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No. A PDF is a static file. It is however possible to read text from a PDF file, as per here: https://stackoverflow.com/questions/38592600/how-to-read-pdf-file-in-r – Phil Jun 03 '21 at 14:22
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You could provide a link to a Shiny app in the PDF that runs the code. – Jun 03 '21 at 16:09