Here's a discussion on Shareware trial enforcement with Delphi:
Best Shareware lock for Delphi Win32
Along with discussions on various 3rd-party solutions, techniques for DIY, etc..
IMO, DIY is feasible if your app produces data that the user will want to keep around, then you can simply embed a copy of the usage/day counter in the database in such a way that they can't wipe it without destroying their data. I also like watermarking (printing "trial" on reports, etc..), escalating nag severity, but I do not recommend or condone "drop-dead" crippling until WAY past the expiration data. I also like to measure "days of actual use", instead of using a calendar.
Registry manipulation works, and many of the 3rd-party protectors use it. But you need to be stealthy, and keep backups in several locations simultaneously.
You should also consider having separate trial and registered versions. But also consider that pirates will buy the registered version with a stolen card, and put it on Rapidshare, BitTorrent, etc..
Also note that elaborate defenses lead to support headaches. Sometimes PCs crash and the clock gets set backwards. They install new harware. PCs get rebuilt, restored from backup, etc.. If a user is running a debugger, he may be a software developer, not a pirate. If your app looks like it has been patched, it may be an overly-aggressive antivirus. And at any time, a shoddy patch for Windows may cause your program to think that it's being attacked, hacked, or reverse-engineered. You have been warned...