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That is, if given the sequence GGCCAATT, the program would return AATTGGCC? And the program must also work regardless of whitespace (spaces or tabs), case, and line breaks.

Banana nana
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  • I think this [post](https://stackoverflow.com/questions/25188968/reverse-complement-of-dna-strand-using-python) answers your question – rachelyw Sep 28 '21 at 18:45

3 Answers3

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Assuming the sequence is a string replace should do the trick:

sequence = 'GGCCAATT'
swap_A_G = sequence.replace('G', 'X').replace('A', 'G').replace('X', 'A')
swap_T_C = swap_A_G.replace('T', 'X').replace('C', 'T').replace('X', 'C')

It's ugly, but stringmethods are pretty fast.

mapf
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Try this:

import re

my_dna='G    g \t C   cA\n   A t    T'

def my_func(dna_seq):
    Output=(re.sub('\s*','', dna_seq)[4:]+re.sub('\s*','', dna_seq)[:4]).upper()
    return Output

my_dna:

print(my_dna)

G    g   C   cA
   A t    T

Output:

my_func(my_dna)

'AATTGGCC'
j__carlson
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If you are trying to deal with dna sequencing Biopython is a module in python you are searching for. you can easily get the reverse complement as follows.

from Bio.Seq import Seq

seq=Seq('GGCCAATT')
dna=seq.reverse_complement()
print(dna)//AATTGGCC
Nishani Kasineshan
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