You could use the freetds module. GitHub repository was active 5 days ago, it aims to provide support for sybase and MSQL Server.
I used it with MSQL
You can download it from there, and installing with the instruction on this link (Sybase python module website)
Then you can test your installation using these steps
You can also try different Django version.
If this doesn't show anything wrong, and Django still won't connect to your DB, you can try to edit Django's source files so the ImproperlyConfigured exception doesn't raise (REALLY REALLY RISKY, DO A BACK UP OF YOUR DB) or migrate your Sybase to a supported database.