Would it not be better to have one click routine - all buttons can freely point to that one click routine - but inside of that click routine, you can freely check the value(s) of the given text boxes, and then run the desired code. This seems a whole lot less complex then trying to change what actual button supposed to be clicked. So, have all buttons run the SAME routine, but that routine can simple check which text boxes have values in them.
Then based on what text boxes have (or have not) a value, you simple run or call the code you want based on this information.
Keep in mind, that in most cases, hitting enter key will trigger the button that FOLLOWS the control in the markup after that text box.
Edit: correction: the FIRST button on the page will trigger.
However, you can TURN OFF this behavour by setting in the button markup usesubmitBehaviour=False
<asp:TextBox ID="txtSearchOC" runat="server"></asp:TextBox>
<asp:Button ID="Button1" runat="server" Text="Button"
UseSubmitBehavior="False" />
In fact, if you drop a text box on a form, then say a gridview with 10 rows, and each row of the gridviewe has button with click event? Hitting enter key in above will in fact trigger the FIRST row button click of the gridview!!!
So, often by correct placement of buttons, say like a search text box, and a button after to click "search data", then in fact, if they hit enter key, the button that follows that text box will trigger anyway. (as noted, first button on markup fires - not any button, or not actually the one that follows the textbox).
So, in some cases, the correct order of a text box, and the button that follows can be put to good use here. But, often it can surprise you. You drop in a text box, and a form has 10 buttons that follow, ONE of them WILL trigger when you hit enter key - and this can often be harder to PREVENT this from occurring.
So, keep the above in mind. but, given that you want code to run based on values in text boxes (or lack of values), then I would have ONE routine that the button clicks ALL use, and the code behind can then check the text box values, and take the desired course of action and run your desired code based on this information.