The Needleman-Wunch Algorithm
Biologists sometimes try to align the DNA of two different plants or animals to see how much of their genome they share in common.
MOUSE: A A T C C G C T A G
RAT: A A A C C C T T A G
+ + - + + - - + + +
Above "+
" means that pieces of DNA match.
Above "-
" means that pieces of DNA mis-match.
You can use the full ASCII character set (128 characters) instead of the letters ATCG
that biologists use.
I recommend using the the Needleman Wunsch Algorithm
Needle-Wunsch is not the fastest algorithm in the world.
However, Needle-Wunsch is easy to understand.
In cases were one string of English text is completely missing a word present in the other text, Needleman Wunsch will match the word to special "GAP" character.
+-------+--------+-------+---+------+----+-----+-------+-----+----+-----+-------+------+
| The | reason | that | I | went | to | the | store | was | to | buy | some | food |
+-------+--------+-------+---+------+----+-----+-------+-----+----+-----+-------+------+
| <GAP> | reason | <GAP> | I | went | 2 | te | store | wuz | 2 | buy | <GAP> | fud |
+-------+--------+-------+---+------+----+-----+-------+-----+----+-----+-------+------+
The special GAP characters are fine.
However, what is in-efficient about Needle Wunsch is that people who wrote the algorithm believed that the order of the gap characters was important. The following are computed as two separate cases:
ALIGNMENT ONE
+---+-------+-------+---+---+
| A | 1 | <GAP> | R | A |
+---+-------+-------+---+---+
| A | <GAP> | B | R | A |
+---+-------+-------+---+---+
ALIGNMENT TWO
+---+-------+-------+---+---+
| A | <GAP> | 1 | R | A |
+---+-------+-------+---+---+
| A | B | <GAP> | R | A |
+---+-------+-------+---+---+
However, if you have two or more gaps in a row, then order of the gaps should not matter.
The Needleman-Wunch algorithm calculates the same thing many times over because whoever wrote the algorithm thought that order mattered a little more than it really does.
The following two alignments have the same score.
Also, both alignments have more or less the same meaning in the "real world" (outside of the computer).
However, the Needleman-Wunch algorithm will compute the scores of the two example alignments twice instead of computing it only one time.