Not exactly sure if this is the best way to do it but at least if your list starts increasing it should work. Then again a bot shouldn't really be made like that.
accept_list = ["yes","of course", "you get my point"]
reject_list = ["no", "i don't think so"]
aiBot = Cleverbot()
r = aiBot.send(question).lower()
ff = ""
if any(ans in r for ans in accept_list):
ff = "yes"
elif any(ans in r for ans in reject_list):
ff = "no"
Suddenly thought about another way though probably still not the best
using_dict = {
"yes":"yes",
"of course": "yes",
"no":"no",
"i don't think so": "no"
}
r = "nope"
try:
ff = using_dict[r]
except:
ff="default value"