Ok, I think I've figured this out. The problem lies with a long-standing issue with Django and Psycopg2. Basically, Psycopg2 will automatically issue a BEGIN statement to the DB. However, if Django thinks no data-modification has occurred, it won't issue a COMMIT at the end of a transaction.
There are a few solutions to this problem, look at http://www.slideshare.net/OReillyOSCON/unbreaking-your-django-application for more details. Ideally you turn off automatic commits (by setting autocommit = True in your DB settings, awkward naming convention). This prevents transactions on read-only functions, but also on write functions so you need to manually wrap those functions in a @commit_on_success decorator.
Alternatively, just add the django.middleware.transaction.TransactionMiddleware to your Middleware classes. This will wrap every request in a transaction. This means also unnecessarily wrapping read-only requests in a transaction, but it's a quick-and-dirty solution.