Well, on paper, normalized form looks to be the best. In real world usually it is a trade-off. Most large systems that I know do trade-offs and not trying to be fully normalized.
I'll try to give an example. If you are in a banking application, with 10 millions passbook account, and the usual transactions will be just a query of the latest balance of certain account. You have table A that stores just those information (account number, account balance, and account holder name).
Your account also have another 40 attributes, such as the customer address, tax number, id for mapping to other systems which is in table B.
A and B have one to one mapping.
In order to be able to retrieve the account balance fast, you may want to employ different index strategy (such as hash index) for the small table that has the account balance and account holder name.
The table that contains the other 40 attributes may reside in different table space or storage, employ different type of indexing, for example because you want to sort them by name, account number, branch id, etc. Your system can tolerate slow retrieval of these 40 attributes, while you need fast retrieval of your account balance query by account number.
Having all the 43 attributes in one table seems to be natural, and probably 'naturally slow' and unacceptable for just retrieving single account balance.