I know that this is possible in principle, but the tools may not exist to do it:
Rather than booting up XP-Mode or some other VM to use Leydesforff's tools (http://www.leydesdorff.net/indicators/index.htm), I'd like a very thin command-line vm that I can use to just run a single 16-bit .exe file and pass input back and forth, i.e.:
vm.exe "oldthing.exe" -options ...
Or, any other way that I can write scripts (.bat, python, something like that) using these 16-bit .exe files that I can run on my Win7 x64 machine...