NCBI is a National Center for Biotechnology Information, one of the most important websites used by bioinformaticians. NCBI runs a big variety of various bioinformatical web services, also provides important databases for download.
The NCBI covers a wide range of bioinformatics resources, from journal listing to gene alignments to chemical libraries databases to protein folding prediction.
NCBI's data is publicly available from the main website and from ftp repositories.
PubMed, a database of citations and abstracts for biomedical literature from MEDLINE and additional life science journals.The NCBI C++ Toolkit provides a set of modules to access, modify, generate and deposit biological data. The full description can be read in its online book
PubChem, a chemical library database, has its own API to search and retrieve chemical compounds