Mixed doubles
2010 US Open
ChampionUnited States Liezel Huber
United States Bob Bryan
Runner-upCzech Republic Květa Peschke
Pakistan Aisam-ul-Haq Qureshi
Score6–4, 6–4

Carly Gullickson and Travis Parrott were the defending champions, but lost in the first round to Gisela Dulko and Pablo Cuevas.

Liezel Huber and Bob Bryan won the title, defeating Květa Peschke and Aisam-ul-Haq Qureshi in the final 6–4, 6–4.

Seeds

  1. United States Liezel Huber / United States Bob Bryan (champions)
  2. Zimbabwe Cara Black / India Leander Paes (quarterfinals)
  3. Slovenia Katarina Srebotnik / Serbia Nenad Zimonjić (second round)
  4. United States Bethanie Mattek-Sands / Canada Daniel Nestor (semifinals)
  5. Australia Rennae Stubbs / Belgium Dick Norman (first round)
  6. Russia Elena Vesnina / Israel Andy Ram (second round)
  7. United States Lisa Raymond / South Africa Wesley Moodie (quarterfinals)
  8. United States Vania King / Romania Horia Tecău (first round)

Draw

Key

Finals

Semifinals Final
          
1 United States Liezel Huber
United States Bob Bryan
6 7  
4 United States Bethanie Mattek-Sands
Canada Daniel Nestor
3 5  
1 United States Liezel Huber
United States Bob Bryan
6 6  
  Czech Republic Květa Peschke
Pakistan Aisam-ul-Haq Qureshi
4 4  
  Czech Republic Květa Peschke
Pakistan Aisam-ul-Haq Qureshi
7 7  
  Germany Anna-Lena Grönefeld
The Bahamas Mark Knowles
65 64  

Top half

First round Second round Quarterfinals Semifinals
1 United States L Huber
United States B Bryan
6 6  
Alt Chinese Taipei S-w Hsieh
Brazil B Soares
4 3   1 United States L Huber
United States B Bryan
5 6 [10]
WC United States M Oudin
United States R Harrison
6 7   WC United States M Oudin
United States R Harrison
7 1 [3]
  Czech Republic A Hlaváčková
Slovakia M Mertiňák
1 5   1 United States L Huber
United States B Bryan
6 7  
  Switzerland T Bacsinszky
Austria O Marach
1 3   7 United States L Raymond
South Africa W Moodie
4 63  
  Belarus O Govortsova
Poland M Matkowski
6 6     Belarus O Govortsova
Poland M Matkowski
4 65  
  Spain A Medina Garrigues
Spain M López
1 64   7 United States L Raymond
South Africa W Moodie
6 7  
7 United States L Raymond
South Africa W Moodie
6 7   1 United States L Huber
United States B Bryan
6 7  
4 United States B Mattek-Sands
Canada D Nestor
6 2 [10] 4 United States B Mattek-Sands
Canada D Nestor
3 5  
WC United States B Capra
United States J Sock
2 6 [7] 4 United States B Mattek-Sands
Canada D Nestor
62 6 [10]
  China Z Yan
India R Bopanna
2 4     France A Rezaï
United States R Ram
7 2 [5]
  France A Rezaï
United States R Ram
6 6   4 United States B Mattek-Sands
Canada D Nestor
6 6  
  Chinese Taipei Y-j Chan
Australia P Hanley
6 6     Chinese Taipei Y-j Chan
Australia P Hanley
4 3  
Alt Romania A Dulgheru
Spain D Marrero
4 2     Chinese Taipei Y-j Chan
Australia P Hanley
6 5 [10]
WC United States A Spears
United States S Lipsky
7 7   WC United States A Spears
United States S Lipsky
2 7 [5]
5 Australia R Stubbs
Belgium D Norman
64 63  

Bottom half

First round Second round Quarterfinals Semifinals
8 United States V King
Romania H Tecău
5 6 [5]
  Czech Republic K Peschke
Pakistan A-u-H Qureshi
7 4 [10]   Czech Republic K Peschke
Pakistan A-u-H Qureshi
5 6 [10]
WC United States J Craybas
United States M Russell
63 7 [1]   Kazakhstan Y Shvedova
Austria J Knowle
7 3 [4]
  Kazakhstan Y Shvedova
Austria J Knowle
7 5 [10]   Czech Republic K Peschke
Pakistan A-u-H Qureshi
3 6 [10]
WC United States C Gullickson
United States T Parrott
2 4     Argentina G Dulko
Uruguay P Cuevas
6 2 [4]
  Argentina G Dulko
Uruguay P Cuevas
6 6     Argentina G Dulko
Uruguay P Cuevas
7 7  
  Germany A Petkovic
Poland M Fyrstenberg
63 62   3 Slovenia K Srebotnik
Serbia N Zimonjić
5 5  
3 Slovenia K Srebotnik
Serbia N Zimonjić
7 7     Czech Republic K Peschke
Pakistan A-u-H Qureshi
7 7  
6 Russia E Vesnina
Israel A Ram
6 66 [11]   Germany A-L Grönefeld
The Bahamas M Knowles
65 64  
WC United States R Kops-Jones
United States E Butorac
4 7 [9] 6 Russia E Vesnina
Israel A Ram
6 3 [7]
  Germany A-L Grönefeld
The Bahamas M Knowles
6 6     Germany A-L Grönefeld
The Bahamas M Knowles
4 6 [10]
WC United States N Gibbs
United States S Querrey
3 2     Germany A-L Grönefeld
The Bahamas M Knowles
6 6  
  Slovakia D Hantuchová
India M Bhupathi
4 2   2 Zimbabwe C Black
India L Paes
3 4  
  Estonia K Kanepi
Sweden R Lindstedt
6 6     Estonia K Kanepi
Sweden R Lindstedt
4 1  
  Czech Republic L Hradecká
Czech Republic F Čermák
4 5   2 Zimbabwe C Black
India L Paes
6 6  
2 Zimbabwe C Black
India L Paes
6 7  
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