ADH4
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesADH4, ADH-2, HEL-S-4, alcohol dehydrogenase 4 (class II), pi polypeptide
External IDsOMIM: 103740 MGI: 1349472 HomoloGene: 20162 GeneCards: ADH4
Orthologs
SpeciesHumanMouse
Entrez

127

26876

Ensembl

ENSG00000198099

ENSMUSG00000037797

UniProt

P08319

Q9QYY9

RefSeq (mRNA)

NM_000670
NM_001306171
NM_001306172

NM_011996

RefSeq (protein)

NP_000661
NP_001293100
NP_001293101

NP_036126

Location (UCSC)Chr 4: 99.12 – 99.16 MbChr 3: 138.12 – 138.14 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Alcohol dehydrogenase 4 is an enzyme that in humans is encoded by the ADH4 gene.[5]

This gene encodes class II alcohol dehydrogenase 4 pi subunit, which is a member of the alcohol dehydrogenase family. Members of this enzyme family metabolize a wide variety of substrates, including ethanol, retinol, other aliphatic alcohols, hydroxysteroids, and lipid peroxidation products. Class II alcohol dehydrogenase is a homodimer composed of 2 pi subunits. It exhibits a high activity for oxidation of long-chain aliphatic alcohols and aromatic alcohols and is less sensitive to pyrazole. This gene is localized to chromosome 4 in the cluster of alcohol dehydrogenase genes.[5]

There is evidence that ancestors of modern humans developed the ADH4 producing gene some 10 million years ago. This probably helped them to take advantage of rotting fruit as they shifted to a terrestrial lifestyle.[6]

References

  1. 1 2 3 GRCh38: Ensembl release 89: ENSG00000198099 - Ensembl, May 2017
  2. 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000037797 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. 1 2 "Entrez Gene: ADH4 alcohol dehydrogenase 4 (class II), pi polypeptide".
  6. Choi CQ (Dec 2, 2014). "Origins of Human Alcohol Consumption Revealed". Scientific American. Retrieved 18 May 2023.

Further reading


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