ADH7
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesADH7, ADH4, alcohol dehydrogenase 7 (class IV), mu or sigma polypeptide
External IDsOMIM: 600086 MGI: 87926 HomoloGene: 37333 GeneCards: ADH7
Orthologs
SpeciesHumanMouse
Entrez

131

11529

Ensembl

ENSG00000196344

ENSMUSG00000055301

UniProt

P40394

Q64437

RefSeq (mRNA)

NM_001166504
NM_000673

NM_009626

RefSeq (protein)

NP_000664
NP_001159976

NP_033756

Location (UCSC)Chr 4: 99.41 – 99.44 MbChr 3: 137.92 – 137.94 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Alcohol dehydrogenase class 4 mu/sigma chain is an enzyme that in humans is encoded by the ADH7 gene.[5][6]

Function

This gene encodes class IV alcohol dehydrogenase 7 mu or sigma subunit, which is a member of the alcohol dehydrogenase family. Members of this family metabolize a wide variety of substrates, including ethanol, retinol, other aliphatic alcohols, hydroxysteroids, and lipid peroxidation products. The enzyme encoded by this gene is inefficient in ethanol oxidation, but is the most active as a retinol dehydrogenase; thus it may participate in the synthesis of retinoic acid, a hormone important for cellular differentiation. The expression of this gene makes it much more abundant in the stomach than the liver, thus it differs from the other known gene family members.[6]

References

  1. 1 2 3 GRCh38: Ensembl release 89: ENSG00000196344 - Ensembl, May 2017
  2. 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000055301 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Satre MA, Zgombić-Knight M, Duester G (Jun 1994). "The complete structure of human class IV alcohol dehydrogenase (retinol dehydrogenase) determined from the ADH7 gene". The Journal of Biological Chemistry. 269 (22): 15606–12. doi:10.1016/S0021-9258(17)40724-1. PMID 8195208.
  6. 1 2 "Entrez Gene: ADH7 alcohol dehydrogenase 7 (class IV), mu or sigma polypeptide".

Further reading


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