EFNA3
Identifiers
AliasesEFNA3, EFL2, EPLG3, Ehk1-L, LERK3, ephrin A3
External IDsOMIM: 601381 MGI: 106644 HomoloGene: 3635 GeneCards: EFNA3
Orthologs
SpeciesHumanMouse
Entrez

1944

13638

Ensembl

ENSG00000143590

ENSMUSG00000028039

UniProt

P52797

O08545

RefSeq (mRNA)

NM_004952

NM_010108

RefSeq (protein)

NP_004943

Location (UCSC)Chr 1: 155.08 – 155.09 MbChr 3: 89.31 – 89.32 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Ephrin A3 is a protein that in humans is encoded by the EFNA3 gene.[5][6]

This gene encodes a member of the ephrin (EPH) family. The ephrins and EPH-related receptors comprise the largest subfamily of receptor protein-tyrosine kinases and have been implicated in mediating developmental events, especially in the nervous system and in erythropoiesis. Based on their structures and sequence relationships, ephrins are divided into the ephrin-A (EFNA) class, which are anchored to the membrane by a glycosylphosphatidylinositol linkage, and the ephrin-B (EFNB) class, which are transmembrane proteins. This gene encodes an EFNA class ephrin.[6]

References

  1. 1 2 3 GRCh38: Ensembl release 89: ENSG00000143590 - Ensembl, May 2017
  2. 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000028039 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Cerretti DP, Lyman SD, Kozlosky CJ, Copeland NG, Gilbert DJ, Jenkins NA, Valentine V, Kirstein MN, Shapiro DN, Morris SW (Jan 1997). "The genes encoding the eph-related receptor tyrosine kinase ligands LERK-1 (EPLG1, Epl1), LERK-3 (EPLG3, Epl3), and LERK-4 (EPLG4, Epl4) are clustered on human chromosome 1 and mouse chromosome 3". Genomics. 33 (2): 277–82. doi:10.1006/geno.1996.0192. PMID 8660976.
  6. 1 2 "Entrez Gene: EFNA3 ephrin-A3".

Further reading



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