LHX2
Identifiers
AliasesLHX2, LH2, hLhx2, LIM homeobox 2
External IDsOMIM: 603759 MGI: 96785 HomoloGene: 55848 GeneCards: LHX2
Orthologs
SpeciesHumanMouse
Entrez

9355

16870

Ensembl

ENSG00000106689

ENSMUSG00000000247

UniProt

P50458

Q9Z0S2

RefSeq (mRNA)

NM_004789

NM_001290646
NM_010710

RefSeq (protein)

NP_004780

NP_001277575
NP_034840

Location (UCSC)Chr 9: 124 – 124.03 MbChr 2: 38.23 – 38.26 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

LIM/homeobox protein Lhx2 is a protein that in humans is encoded by the LHX2 gene.[5][6][7]

This gene encodes a protein belonging to a large protein family, members of which carry the LIM domain, a unique cysteine-rich zinc-binding domain. The encoded protein may function as a transcriptional regulator. The protein can recapitulate or rescue phenotypes in Drosophila caused by a related protein, suggesting conservation of function during evolution.[7]

Interactions

LHX2 has been shown to interact with CITED2.[8]

References

  1. 1 2 3 GRCh38: Ensembl release 89: ENSG00000106689 - Ensembl, May 2017
  2. 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000000247 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Wu HK, Heng HH, Siderovski DP, Dong WF, Okuno Y, Shi XM, Tsui LC, Minden MD (July 1996). "Identification of a human LIM-Hox gene, hLH-2, aberrantly expressed in chronic myelogenous leukaemia and located on 9q33-34.1". Oncogene. 12 (6): 1205–1212. PMID 8649822.
  6. Rincon-Limas DE, Lu CH, Canal I, Calleja M, Rodriguez-Esteban C, Izpisua-Belmonte JC, Botas J (April 1999). "Conservation of the expression and function of apterous orthologs in Drosophila and mammals". Proc Natl Acad Sci U S A. 96 (5): 2165–2170. Bibcode:1999PNAS...96.2165R. doi:10.1073/pnas.96.5.2165. PMC 26754. PMID 10051612.
  7. 1 2 "Entrez Gene: LHX2 LIM homeobox 2".
  8. Glenn, D J; Maurer R A (December 1999). "MRG1 binds to the LIM domain of Lhx2 and may function as a coactivator to stimulate glycoprotein hormone alpha-subunit gene expression". J. Biol. Chem. UNITED STATES. 274 (51): 36159–36167. doi:10.1074/jbc.274.51.36159. ISSN 0021-9258. PMID 10593900.

Further reading


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