PADI1
Identifiers
AliasesPADI1, HPAD10, PAD1, PDI, PDI1, peptidyl arginine deiminase 1
External IDsOMIM: 607934 MGI: 1338893 HomoloGene: 7881 GeneCards: PADI1
Orthologs
SpeciesHumanMouse
Entrez

29943

18599

Ensembl

ENSG00000142623
ENSG00000281459

ENSMUSG00000025329

UniProt

Q9ULC6

Q9Z185

RefSeq (mRNA)

NM_013358

NM_011059

RefSeq (protein)

NP_037490

NP_035189

Location (UCSC)Chr 1: 17.21 – 17.25 MbChr 4: 140.54 – 140.57 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Peptidyl arginine deiminase, type I, also known as PADI1, is a protein which in humans is encoded by the PADI1 gene.[5][6]

This gene encodes a member of the peptidyl arginine deiminase family of enzymes, which catalyze the post-translational deimination of proteins by converting arginine residues into citrullines in the presence of calcium ions. The family members have distinct substrate specificities and tissue-specific expression patterns. The type I enzyme is involved in the late stages of epidermal differentiation, where it deiminates filaggrin and keratin K1, which maintains hydration of the stratum corneum, and hence the cutaneous barrier function. This enzyme may also play a role in hair follicle formation. This gene exists in a cluster with four other paralogous genes.[5]

References

  1. 1 2 3 ENSG00000281459 GRCh38: Ensembl release 89: ENSG00000142623, ENSG00000281459 - Ensembl, May 2017
  2. 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000025329 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. 1 2 "Entrez Gene: PADI1 peptidyl arginine deiminase, type I".
  6. Guerrin M, Ishigami A, Méchin MC, Nachat R, Valmary S, Sebbag M, Simon M, Senshu T, Serre G (February 2003). "cDNA cloning, gene organization and expression analysis of human peptidylarginine deiminase type I". The Biochemical Journal. 370 (Pt 1): 167–74. doi:10.1042/BJ20020870. PMC 1223146. PMID 12416996.

Further reading


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