PIEZO2
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesPIEZO2, C18orf30, C18orf58, DA3, DA5, FAM38B, FAM38B2, HsT748, HsT771, MWKS, piezo type mechanosensitive ion channel component 2, DAIPT
External IDsOMIM: 613629 MGI: 1918781 HomoloGene: 49695 GeneCards: PIEZO2
Orthologs
SpeciesHumanMouse
Entrez

63895

667742

Ensembl

ENSG00000154864

ENSMUSG00000041482

UniProt

Q9H5I5

Q8CD54

RefSeq (mRNA)

NM_022068
NM_173817
NM_001378183

NM_001039485
NM_172629

RefSeq (protein)

NP_071351
NP_001365112

NP_001034574

Location (UCSC)Chr 18: 10.67 – 11.15 MbChr 18: 63.14 – 63.52 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Piezo-type mechanosensitive ion channel component 2 is a protein that in humans is encoded by the PIEZO2 gene.[5] It has a homotrimeric structure, with three blades curving into a nano-dome, with a diameter of 28 nanometers.[6]

Function

Piezos are large transmembrane proteins conserved among various species, all having between 24 and 36 predicted transmembrane domains. 'Piezo' comes from the Greek 'piesi,' meaning 'pressure.' The PIEZO2 protein has a role in rapidly adapting mechanically activated (MA) currents in somatosensory neurons.[7] Its structure is resolved via a mouse version in 2019, showing the predicted homotrimeric propeller.[8]

PIEZO2 is typically found in cell types that respond to physical touch, such as Merkel cells,[9] and is thought to regulate light touch response.[10]

Pathology

See also

References

  1. 1 2 3 GRCh38: Ensembl release 89: ENSG00000154864 - Ensembl, May 2017
  2. 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000041482 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. "Entrez Gene: Piezo-type mechanosensitive ion channel component 2". Retrieved 2013-08-06.
  6. Wang L, Zhou H, Zhang M, Liu W, Deng T, Zhao Q, et al. (September 2019). "Structure and mechanogating of the mammalian tactile channel PIEZO2". Nature. 573 (7773): 225–229. Bibcode:2019Natur.573..225W. doi:10.1038/s41586-019-1505-8. PMID 31435011. S2CID 201116189.
  7. Coste B, Mathur J, Schmidt M, Earley TJ, Ranade S, Petrus MJ, et al. (October 2010). "Piezo1 and Piezo2 are essential components of distinct mechanically activated cation channels". Science. 330 (6000): 55–60. Bibcode:2010Sci...330...55C. doi:10.1126/science.1193270. PMC 3062430. PMID 20813920.
  8. Wang L, Zhou H, Zhang M, Liu W, Deng T, Zhao Q, et al. (September 2019). "Structure and mechanogating of the mammalian tactile channel PIEZO2". Nature. 573 (7773): 225–229. Bibcode:2019Natur.573..225W. doi:10.1038/s41586-019-1505-8. PMID 31435011. S2CID 201116189.
  9. Wu J, Lewis AH, Grandl J (January 2017). "Touch, Tension, and Transduction - The Function and Regulation of Piezo Ion Channels". Trends in Biochemical Sciences. 42 (1): 57–71. doi:10.1016/j.tibs.2016.09.004. PMC 5407468. PMID 27743844.
  10. Faucherre A, Nargeot J, Mangoni ME, Jopling C (October 2013). "piezo2b regulates vertebrate light touch response". The Journal of Neuroscience. 33 (43): 17089–94. doi:10.1523/jneurosci.0522-13.2013. PMC 6618434. PMID 24155313.
  11. Coste B, Houge G, Murray MF, Stitziel N, Bandell M, Giovanni MA, et al. (March 2013). "Gain-of-function mutations in the mechanically activated ion channel PIEZO2 cause a subtype of Distal Arthrogryposis". Proceedings of the National Academy of Sciences of the United States of America. 110 (12): 4667–72. Bibcode:2013PNAS..110.4667C. doi:10.1073/pnas.1221400110. PMC 3607045. PMID 23487782.
  12. Woo SH, Lukacs V, de Nooij JC, Zaytseva D, Criddle CR, Francisco A, et al. (December 2015). "Piezo2 is the principal mechanotransduction channel for proprioception". Nature Neuroscience. 18 (12): 1756–62. doi:10.1038/nn.4162. PMC 4661126. PMID 26551544.
  13. McMillin MJ, Beck AE, Chong JX, Shively KM, Buckingham KJ, Gildersleeve HI, et al. (May 2014). "Mutations in PIEZO2 cause Gordon syndrome, Marden-Walker syndrome, and distal arthrogryposis type 5". American Journal of Human Genetics. 94 (5): 734–44. doi:10.1016/j.ajhg.2014.03.015. PMC 4067551. PMID 24726473.

Further reading

This article incorporates text from the United States National Library of Medicine, which is in the public domain.


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