Paolucci, also spelled Paulucci, and historically scarcely as Paoluzzi, Pauluzzi and Paluzzi is an Italian surname deriving from the given name Paolo (Paulus). It may refer to:

• Amilcare Paulucci (1773–1845), Italian admiral
• Adriano Paolucci (born 1979), Italian male volleyball player
• Andrea Paolucci (born 1986), Italian footballer.
• Anne Paolucci (1926–2012), Italian-American writer, scholar, and educator
• Antonio Paolucci (born 1939), Italian art historian and curator
• Cristian Paulucci (born 1973), Argentine footballer
• Fabrizio Paolucci (bishop), (1565–1625), Roman Catholic prelate who served as Bishop of Città della Pieve
• Fabrizio Paolucci (1651–1726), Catholic cardinal
• Fabrizio Paolucci (1726–1810)
• Federico Paulucci (born 1990), Argentine footballer
• Gianfranco Paolucci (born 1934), Italian fencer
• Gustavo Paolucci (born 1954), Argentine field hockey player
• Jeno Paulucci (1918–2011), American businessman and entrepreneur
• Lorenzo Paolucci (born 1996), Italian football player
• Loris Paoluzzi (born 1974), Italian retired male hammer thrower
• Luciana Paluzzi (born 1937), Italian actress
• Marianna Paulucci (1835–1919), Italian naturalist
• Mario Paolucci (1941–2008), Argentine film actor
• Michele Paolucci (born 1986), Italian footballer
• Pauluccio Paulucci-Alberoni (fl. 1670–1676), Catholic cardinal and coadjutor to Pope Clement X
• Philip Osipovich Paulucci (1779–1849), Italian marquis, served in the Russian Army as adjutant general
• Roland Paolucci (born 1947), retired Swiss footballer