RGS11
Identifiers
AliasesRGS11, RS11, regulator of G-protein signaling 11, regulator of G protein signaling 11
External IDsOMIM: 603895 MGI: 1354739 HomoloGene: 77719 GeneCards: RGS11
Orthologs
SpeciesHumanMouse
Entrez

8786

50782

Ensembl

ENSG00000076344

ENSMUSG00000024186

UniProt

O94810

Q9Z2H1

RefSeq (mRNA)

NM_001286485
NM_001286486
NM_003834
NM_183337

NM_001081069

RefSeq (protein)

NP_001273414
NP_001273415
NP_003825
NP_899180

NP_001074538

Location (UCSC)Chr 16: 0.27 – 0.28 MbChr 17: 26.42 – 26.43 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Regulator of G-protein signaling 11 is a protein that in humans is encoded by the RGS11 gene.[5][6]

The protein encoded by this gene belongs to the RGS (regulator of G protein signaling) family. Members of the RGS family act as GTPase-activating proteins on the alpha subunits of heterotrimeric, signal-transducing G proteins. This protein inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits, thereby driving them into their inactive GDP-bound form. Alternative splicing occurs at this locus and two transcript variants encoding distinct isoforms have been identified.[6]

References

  1. 1 2 3 GRCh38: Ensembl release 89: ENSG00000076344 - Ensembl, May 2017
  2. 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000024186 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Snow BE, Krumins AM, Brothers GM, Lee SF, Wall MA, Chung S, Mangion J, Arya S, Gilman AG, Siderovski DP (Nov 1998). "A G protein gamma subunit-like domain shared between RGS11 and other RGS proteins specifies binding to Gbeta5 subunits". Proc Natl Acad Sci U S A. 95 (22): 13307–12. Bibcode:1998PNAS...9513307S. doi:10.1073/pnas.95.22.13307. PMC 23793. PMID 9789084.
  6. 1 2 "Entrez Gene: RGS11 regulator of G-protein signalling 11".

Further reading


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