RNF139
Identifiers
AliasesRNF139, HRCA1, RCA1, TRC8, ring finger protein 139
External IDsOMIM: 603046 MGI: 1923091 HomoloGene: 5222 GeneCards: RNF139
Orthologs
SpeciesHumanMouse
Entrez

11236

75841

Ensembl

ENSG00000170881

ENSMUSG00000037075

UniProt

Q8WU17

Q7TMV1

RefSeq (mRNA)

NM_007218

NM_175226

RefSeq (protein)

NP_009149

NP_780435

Location (UCSC)Chr 8: 124.47 – 124.49 MbChr 15: 58.76 – 58.78 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

RING finger protein 139, also known as TRC8, is a protein that in humans is encoded by the RNF139 gene.[5][6]

The protein encoded by this gene is a multi-membrane spanning protein containing a RING-H2 finger. This protein is located in the endoplasmic reticulum, and has been shown to possess ubiquitin ligase activity. This gene was found to be interrupted by a t(3:8) translocation in a family with hereditary renal and non-medullary thyroid cancer. Studies of the Drosophila counterpart suggested that this protein may interact with tumor suppressor protein VHL, as well as with COPS5/JAB1, a protein responsible for the degradation of tumor suppressor CDKN1B/P27KIP].[6]

References

  1. 1 2 3 GRCh38: Ensembl release 89: ENSG00000170881 - Ensembl, May 2017
  2. 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000037075 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Gemmill RM, West JD, Boldog F, Tanaka N, Robinson LJ, Smith DI, Li F, Drabkin HA (Sep 1998). "The hereditary renal cell carcinoma 3;8 translocation fuses FHIT to a patched-related gene, TRC8". Proc Natl Acad Sci U S A. 95 (16): 9572–7. Bibcode:1998PNAS...95.9572G. doi:10.1073/pnas.95.16.9572. PMC 21380. PMID 9689122.
  6. 1 2 "Entrez Gene: RNF139 ring finger protein 139".

Further reading


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