| SETD1B | |||||||||||||||||||||||||||||||||||||||||||||||||||
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| Identifiers | |||||||||||||||||||||||||||||||||||||||||||||||||||
| Aliases | SETD1B, KMT2G, Set1B, SET domain containing 1B, SET domain containing 1B, histone lysine methyltransferase, IDDSELD | ||||||||||||||||||||||||||||||||||||||||||||||||||
| External IDs | OMIM: 611055 HomoloGene: 137311 GeneCards: SETD1B | ||||||||||||||||||||||||||||||||||||||||||||||||||
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| Wikidata | |||||||||||||||||||||||||||||||||||||||||||||||||||
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SET domain containing 1B is a protein that in humans is encoded by the SETD1B gene. [3]
Function
SET1B is a component of a histone methyltransferase complex that produces trimethylated histone H3 at Lys4 (Lee et al., 2007 [PubMed 17355966]).[supplied by OMIM, Mar 2008].
References
- 1 2 3 GRCh38: Ensembl release 89: ENSG00000139718 - Ensembl, May 2017
- ↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ↑ "Entrez Gene: SET domain containing 1B". Retrieved 2018-01-13.
Further reading
- Lee JH, Skalnik DG (2012). "Rbm15-Mkl1 interacts with the Setd1b histone H3-Lys4 methyltransferase via a SPOC domain that is required for cytokine-independent proliferation". PLOS ONE. 7 (8): e42965. Bibcode:2012PLoSO...742965L. doi:10.1371/journal.pone.0042965. PMC 3424240. PMID 22927943.
- Choi YJ, Oh HR, Choi MR, Gwak M, An CH, Chung YJ, Yoo NJ, Lee SH (2014). "Frameshift mutation of a histone methylation-related gene SETD1B and its regional heterogeneity in gastric and colorectal cancers with high microsatellite instability". Hum. Pathol. 45 (8): 1674–81. doi:10.1016/j.humpath.2014.04.013. PMID 24925220.
- Labonne JD, Lee KH, Iwase S, Kong IK, Diamond MP, Layman LC, Kim CH, Kim HG (2016). "An atypical 12q24.31 microdeletion implicates six genes including a histone demethylase KDM2B and a histone methyltransferase SETD1B in syndromic intellectual disability". Hum. Genet. 135 (7): 757–71. doi:10.1007/s00439-016-1668-4. PMID 27106595. S2CID 3760488.
- Kranz, Andrea; Anastassiadis, Konstantinos (2020). "The role of SETD1A and SETD1B in development and disease". Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms. 1863 (8): 194578. doi:10.1016/j.bbagrm.2020.194578. ISSN 1874-9399. PMID 32389824. S2CID 218585660.
- Brici, David; Zhang, Qinyu; Reinhardt, Susanne; Dahl, Andreas; Hartmann, Hella; Schmidt, Kerstin; Goveas, Neha; Huang, Jiahao; Gahurova, Lenka; Kelsey, Gavin; Anastassiadis, Konstantinos; Stewart, A. Francis; Kranz, Andrea (2017). "The histone 3 lysine 4 methyltransferase Setd1b is a maternal effect gene required for the oogenic gene expression program". Development. 144 (14): 2606–2617. doi:10.1242/dev.143347. ISSN 1477-9129. PMID 28619824.
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