std140 is most useful when you have a uniform block that you update all at once, for example a collection of matrix and lighting values for rendering a scene. Declare the block with std140 in your shader(s), and you can replicate the memory layout in C with a struct. Instead of having to query and save the offsets for every individual value within the block from C, you can just glBufferData(GL_UNIFORM_BUFFER, sizeof(my_struct), &my_struct, with one call.
You do need to be a little careful with alignment in C, for instance, a vec3 will take up 4 floats, not 3, but it is still much easier IMHO.