I'm also curious that which i/o request uses thread pool.
Disk I/O uses the thread pool.
Network I/O is async from the beginning and does not use threads.
With disk I/O, the individual disk I/O calls still present to Javascript as non-blocking and asynchronous even though they use threads in their native code implementation. When you exceed more disk I/O calls in process than the size of the thread pool, the disk I/O calls are queued and when one of the threads frees up, the next disk I/O call in the queue will run using that now available thread. Since the Javascript for the disk I/O is all non-blocking and assumes a completion callback will get called sometime in the future, the queuing of requests when the thread pool is all busy just means it will take longer to get to the later I/O requests, but otherwise the Javascript programming interface is not affected.
Given that I have a quad-core computer and libuv thread pool size of 4, will Node.js utilize all those 4 cores when processing lots of i/o requests(maybe more than thousands)?
This is not up to node.js and is hard to answer in the absolute for that reason. The first referenced article below says that on Linux, the I/O thread pool will use multiple cores and offers a small demo app that shows that.
This is up to the specific OS implementation and the thread scheduler that it uses. node.js just happily creates the threads and uses them and the OS then decides how to make use of the CPU given what it is being asked to do overall on the system. Since threads in the same process often have to communicate with one another in some way, using a separate CPU for different threads in the same process is a lot more complicated.
There are a couple node.js design patterns that are guaranteed to take advantage of multiple cores (in any modern OS)
Cluster your app and create as many clusters as you have processor cores. This also has the advantage that each cluster has its own I/O thread pool that can work independently and each can execute it's own Javascript independently. With only one node.js process and multiple cores, you never get more than one thread of Javascript execution (this is where node.js is referred to as single threaded - even though it does use threads in its library implementations). But, with clustering, you get independent Javascript execution for each clustered server process.
For individual tasks that might be CPU-intensive (for example, image processing), you can create a work queue and a pool of child worker processes that you hand work off to. This has some benefits in common with clustering, but it is more special purpose where you know exactly where the CPU bottleneck is and you want to attack it specifically.
Other related answers/articles:
how libuv threads in nodejs utilize multi core cpu
Node.js on multi-core machines
Taking Advantage of Multi-Processor Environments in node.js
When is the thread pool used?