One important point to note here is that an image can have some blurry areas and some sharp areas. For example, if an image contains portrait photography, the image in the foreground is sharp whereas the background is blurry. In sports photography, the object in focus is sharp and the background usually has motion blur. One way to detect such a spatially varying blur in an image is to run a frequency domain analysis at every location in the image. One of the papers which addresses this topic is "Spatially-Varying Blur Detection Based on Multiscale Fused and Sorted Transform Coefficients of Gradient Magnitudes" (cvpr2017).
the authors look at multi resolution DCT coefficients at every pixel. These DCT coefficients are divided into low, medium, and high frequency bands, out of which only the high frequency coefficients are selected.
The DCT coefficients are then fused together and sorted to form the multiscale-fused and sorted high-frequency transform coefficients
A subset of these coefficients are selected. the number of selected coefficients is a tunable parameter which is application specific.
The selected subset of coefficients are then sent through a max pooling block to retain the highest activation within all the scales. This gives the blur map as the output, which is then sent through a post processing step to refine the map.
This blur map can be used to quantify the sharpness in various regions of the image. In order to get a single global metric to quantify the bluriness of the entire image, the mean of this blur map or the histogram of this blur map can be used
Here are some examples results on how the algorithm performs:

The sharp regions in the image have a high intensity in the blur_map, whereas blurry regions have a low intensity.
The github link to the project is: https://github.com/Utkarsh-Deshmukh/Spatially-Varying-Blur-Detection-python
The python implementation of this algorithm can be found on pypi which can easily be installed as shown below:
pip install blur_detector
A sample code snippet to generate the blur map is as follows:
import blur_detector
import cv2
if __name__ == '__main__':
img = cv2.imread('image_name', 0)
blur_map = blur_detector.detectBlur(img, downsampling_factor=4, num_scales=4, scale_start=2, num_iterations_RF_filter=3)
cv2.imshow('ori_img', img)
cv2.imshow('blur_map', blur_map)
cv2.waitKey(0)