When it says users are connected, what does the query "select * from pg_stat_activity;" say? Are the other users besides yourself now connected? If so, you might have to edit your pg_hba.conf file to reject connections from other users, or shut down whatever app is accessing the pg database to be able to drop it. I have this problem on occasion in production. Set pg_hba.conf to have a two lines like this:
local all all ident
host all all 127.0.0.1/32 reject
and tell pgsql to reload or restart (i.e. either sudo /etc/init.d/postgresql reload or pg_ctl reload) and now the only way to connect to your machine is via local sockets. I'm assuming you're on linux. If not this may need to be tweaked to something other than local / ident on that first line, to something like host ... yourusername.
Now you should be able to do:
psql postgres
drop database mydatabase;