HOXB2
Identifiers
AliasesHOXB2, HOX2, HOX2H, Hox-2.8, K8, homeobox B2
External IDsOMIM: 142967 MGI: 96183 HomoloGene: 37584 GeneCards: HOXB2
Orthologs
SpeciesHumanMouse
Entrez

3212

103889

Ensembl

ENSG00000173917

ENSMUSG00000075588

UniProt

P14652

P0C1T1

RefSeq (mRNA)

NM_002145

NM_134032

RefSeq (protein)

NP_002136

NP_598793

Location (UCSC)Chr 17: 48.54 – 48.55 MbChr 11: 96.24 – 96.24 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Homeobox protein Hox-B2 is a protein that in humans is encoded by the HOXB2 gene.[5][6][7]

Function

This gene is a member of the Antp homeobox family and encodes a nuclear protein with a homeobox DNA-binding domain. It is included in a cluster of homeobox B genes located on chromosome 17. The encoded protein functions as a sequence-specific transcription factor that is involved in development. Increased expression of this gene is associated with pancreatic cancer.[7]

See also

References

  1. 1 2 3 GRCh38: Ensembl release 89: ENSG00000173917 - Ensembl, May 2017
  2. 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000075588 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. McAlpine PJ, Shows TB (Jul 1990). "Nomenclature for human homeobox genes". Genomics. 7 (3): 460. doi:10.1016/0888-7543(90)90186-X. PMID 1973146.
  6. Scott MP (Nov 1992). "Vertebrate homeobox gene nomenclature". Cell. 71 (4): 551–3. doi:10.1016/0092-8674(92)90588-4. PMID 1358459. S2CID 13370372.
  7. 1 2 "Entrez Gene: HOXB2 homeobox B2".

Further reading

This article incorporates text from the United States National Library of Medicine, which is in the public domain.


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