This is a non-trivial problem. But the basics are a CGRect is a rectangle and a hit test inside of a rectangle is fairly easy to understand. However, you sound like you want a more complex shape. UIImageView displays an image. It does not have any idea about what shape you want to use for your collision test. So you are going to have to tell it.
One easy thing to do is to look at the alpha/transparent values of the display image to create a shape. So to answer the question is a point hitting an image we figure out the location of point in the image and return true if the alpha is greater than 0. If you do this you can create any image with a transparent background and the code will just work.
If that will not work for you then can can also run a hit test on a point and a polygon this post covers that in detail.
How can I determine whether a 2D Point is within a Polygon?